[Hiring] Director, Commercial Manufacturing Operations @Praxis Precision Medicines, Inc.

Role Description

This position may be performed remotely but requires flexibility and a willingness to travel (approximately 40–60%) to CDMO manufacturing sites, including international travel as needed.

As Director, Commercial Manufacturing Operations, you will serve as the operational leader for commercial manufacturing of an assigned product. Acting as Praxis's "virtual plant manager," you will own day-to-day manufacturing performance across one or more CDMO partners, ensuring reliable supply, operational excellence, and continuous improvement throughout the commercial lifecycle.

This is not a project management or technical transfer role. It is an operations leadership role focused on delivering consistent commercial execution through influence, partnership, and disciplined operational management. You'll build strong relationships across Manufacturing, Quality, Supply Chain, MSAT, Procurement, and our external partners to anticipate risks, solve problems quickly, and continuously raise performance standards.

Success in this role means patients receive uninterrupted access to medicines because our manufacturing network consistently delivers safe, compliant, high-quality product.

Primary Responsibilities

• Serve as the operational owner for commercial manufacturing performance at assigned CDMO partners, ensuring reliable execution of production schedules, supply commitments, and operational readiness.
• Lead a cross-functional Virtual Manufacturing Team, aligning Manufacturing, MSAT, Quality, Supply Chain, Procurement, Regulatory, and Analytical Development around a common operational plan and clear priorities.
• Develop deep operational visibility into manufacturing performance, proactively identifying staffing, equipment, material, scheduling, and compliance risks before they impact patients or supply.
• Drive operational excellence by establishing meaningful performance metrics, monitoring trends, and partnering with CDMO leadership to improve right-first-time performance, schedule adherence, cycle times, yields, and overall manufacturing reliability.
• Partner closely with Quality to ensure deviations, investigations, CAPAs, change controls, and audit observations are addressed with urgency while maintaining the highest standards of GMP compliance.
• Lead operational response during manufacturing issues, acting as the primary Praxis representative during batch-at-risk events, supply disruptions, or significant operational escalations.
• Champion a culture of continuous improvement by identifying and implementing initiatives that improve operational performance, reduce cost, increase capacity, and strengthen long-term CDMO capabilities.

Qualifications

• Bachelor’s degree in engineering, pharmaceutical sciences, chemistry or a related discipline; advanced degree preferred.
• 15+ years of pharmaceutical or biotechnology manufacturing experience, including significant leadership experience supporting commercial GMP operations.
• Demonstrated experience leading manufacturing operations at a commercial manufacturing site (Plant Manager, Operations Leader, or equivalent operational leadership role).
• Significant experience managing external manufacturing partners (CDMOs) supporting commercial products.
• Strong knowledge of commercial manufacturing operations, GMP regulations, quality systems, deviation management, CAPA processes, and continuous improvement methodologies.
• Demonstrated ability to influence cross-functional teams and external partners without direct reporting authority.
• Excellent communication skills with the ability to translate operational complexity into clear business decisions for senior leadership.

Requirements

• The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement.
• Comfort with screen work, basic hand coordination, and sustained focus.
• Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.

Benefits

• 99% of the premium paid for medical, dental and vision plans.
• Company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage.
• Dollar-for-dollar match up to 6% on eligible 401(k) contributions.
• Long-term stock incentives and ESPP.
• Discretionary quarterly bonus.
• Extremely flexible wellness benefit.
• Generous PTO, paid holidays, and company-wide shutdowns.
• Joining a phenomenal crew of colleagues who are smart, engaged, and inspiring.

Company Description

Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders.

• Core Values: Trust, Ownership, Curiosity, and Results.
• Commitment to diversity, equity, and inclusion.