[Hiring] Senior Scientist I @Simulations Plus

Role Description

The Senior Scientist I will lead or contribute to the technical execution of consulting projects using Quantitative Systems Pharmacology (QSP) and/or Toxicology (QST) models and methodologies. Frequently, consulting projects are conducted in Simulations Plus models, leveraging technical expertise in MATLAB or THALES.

• Design, write, test, and use computer code to build and maintain the sub-model(s), representing core cellular, molecular, and/or biochemical processes in a given model.
• Represent compound pharmacodynamics (PD) and/or mechanism of action (MoA), including translating laboratory data into model parameters and curation of clinical data for calibration/validation.
• Learn and effectively utilize the company agentic AI solutions for technical work.
• Lead or contribute to the activities required for successful completion of all goals within consulting projects.
• Lead or contribute (as time allows) to R&D efforts, including updating the “license-ready” versions of the various models and supporting ongoing development of QST models of liver injury (i.e., the DILI-sim consortium).
• Combine technical and project management work, including components such as systems pharmacology modeling, software code development, and maintenance in designated software environments.
• Develop plans to complete all tasks and provide all deliverables within a time frame consistent with the services agreement signed with the sponsor.
• Identify and suggest mitigation strategies for risks to successful project completion on time and on budget.
• Schedule the necessary meetings including internal and external collaborators.
• Exert leadership in the areas of report and presentation preparation, including evidence of minimal required supervision and providing thoughtful feedback on messaging.
• Lead consulting projects, upon demonstrating the necessary technical and project management skills and availability of a suitable project.
• Identify and initiate departmental activities that support growth or improved efficiency in the QSP team.
• Participate in preparation and review of joint manuscripts between the company and the sponsor.
• Manage the effort expended for a given project to remain consistent with the resources allocated for the project per the signed contract.
• Publish work in scientific journals, with minimal review required by their supervisor, including documentation preparation, text development, figure development, and correspondence with editors and peer reviewers.
• Oversee and supervise the technical work of others and mentor less experienced scientists.
• Train others on QSP/QST and the various models.
• Other duties as assigned.

Qualifications

• 5+ years of QSP/QST modeling experience or demonstration of the equivalent skill sets.
• Proficiency in mathematics, dynamic systems, drug development, pharmacology.
• General knowledge of relevant therapeutic areas, including clinical endpoints and underlying cell and molecular biology and/or biochemistry.
• Experience with MATLAB, THALES, Julia, SimBiology, Monolix, GastroPlus™, and/or C++ programming.
• Experience with PBPK, PK, popPK and/or PKPD modeling.
• Basic familiarity with large-language models and agentic AI.
• Understand how to apply modeling and simulation for maximum impact and effective means to communicate to non-modeling audiences.
• Strong verbal and written communication skills.
• Maintains a positive attitude while interacting with colleagues and clients.
• Must be able to multitask and have good organizational skills.
• Self-motivated with ability to work with minimal supervision.
• Occasional travel for conferences, meeting, and training.

Education

• Master’s degree in pharmaceutical science, biomedical engineering, or related life sciences field.
• PhD in pharmaceutical science, biomedical engineering, or related life sciences field preferred.