[Hiring] Senior Scientist / Engineer @Intertwine Associates

Role Description

Work in a dynamic, fast-paced environment as a Senior Scientist / Engineer supporting the Advanced Research Projects Agency for Health (ARPA-H) across a portfolio spanning:

• Transplantation
• Organ and tissue preservation
• Engineered tissues
• Organoids and microphysiological systems (MPS)
• Advanced therapeutic manufacturing

Collaborate with the ARPA-H Program Manager and team to effectuate bold research initiatives; support the development, funding, and management of new and existing R&D programs; and help the agency accelerate better health outcomes for everyone.

Provide direct technical support to:

• R&D performer teams
• Government Program Managers
• Stakeholders across the health innovation ecosystem

Bring deep technical expertise in transplantation and/or regenerative medicine, and apply it to emerging technologies in the context of:

• Clinical workflow
• Manufacturability
• Regulatory constraints
• Real-world implementation

Evaluate technologies in the context of clinical and operational realities, including:

• Donor tissue and organ recovery
• Preservation logistics and cold-chain constraints
• Perfusion-enabled assessment and intervention
• Transplant-center workflow

Conduct landscape analyses and technical diligence on:

• Emerging capabilities
• Vendors
• Performers
• Scientific trends

Assess the commercialization pathway alongside the science, including:

• Scale-up and manufacturability
• Quality systems and GMP considerations
• Regulatory strategy
• Reimbursement context
• Supply chain
• Clinical adoption barriers

Provide insight into how innovations may intersect with the broader transplant ecosystem, including:

• Organ procurement organizations
• Transplant centers
• Tissue banks
• Applicable federal regulators and stakeholders

Review and assess:

• Technical proposals
• Performer submissions
• Milestones
• Deliverables
• Program risks

Provide feedback, organize reviewer comments, and draft:

• Recommendations
• Project summaries
• Presentation materials

Help identify:

• Subject-matter experts
• Potential performers
• Test and evaluation partners
• Transition stakeholders across academia, industry, clinical practice, and government

Assist in program management functions, including:

• Preparing for technical meetings
• Conducting site visits
• Consolidating performer progress
• Identifying schedule risks
• Creating briefing materials

Maintain awareness of relevant scientific, clinical, regulatory, and market developments.

Strong client or customer engagement is required in this role. You will interface directly and continuously with:

• Government Program Manager
• Mission Office leadership
• Performer teams
• External stakeholders across the transplant and bioengineering communities

You are expected to represent Intertwine Associates and the client with professionalism, responsiveness, and sound judgment at every touchpoint. This is a remote position with approximately 10-20% CONUS travel.

Qualifications

• Advanced degree in a relevant field: PhD in physiology, systems biology, bioengineering, tissue engineering, regenerative medicine, or a related discipline; or MD with significant experience in transplantation, organ preservation, transplant surgery, transplant medicine, or a closely related field.
• Demonstrated subject-matter expertise in one or more of the following: organ preservation, ex vivo organ perfusion and diagnostics, transplant biology, regenerative medicine, translational bioengineering.
• Demonstrated ability to critically evaluate technical data, experimental plans, and development pathways.
• Experience synthesizing complex scientific information into concise written and visual products for decision support.
• Experience supporting complex R&D efforts involving academic, clinical, and/or industrial stakeholders.
• Demonstrated ability to translate between basic science, engineering development, and clinical or transplant operational realities.
• Team-oriented with strong interpersonal skills and the ability to work across multidisciplinary teams.
• Excellent written and verbal communication skills, both internally and externally with members of the public.
• Ability to work independently and collaboratively as part of a team, and to prioritize work.
• Highly detail-oriented, organized, and proactive.
• Strong work ethic and a passion for healthcare and scientific discovery.
• U.S. citizenship or lawful permanent residency is required per contract.
• Active federal government Public Trust, or the ability to obtain one.

Requirements

• Direct experience in transplantation, including clinical, translational, or operational work related to donor organ recovery, preservation, allocation, or implantation.
• Experience working in or with: HRSA, OPTN/UNOS, organ procurement organizations (OPOs), transplant centers, tissue banks or organ recovery networks or programs involving cross-sector coordination.
• Familiarity with the practical and policy dimensions of the U.S. transplant ecosystem.
• Experience with organ perfusion technologies for assessment, preservation, repair, or treatment of donor organs.
• Experience with biopreservation approaches, including hypothermic and normothermic preservation, supercooling, cryopreservation, vitrification, and cold-chain logistics.
• Experience with engineered tissues, organoids, organ-on-chip or microphysiological systems (MPS), biofabrication, or advanced therapeutic manufacturing.
• Experience with translational and commercialization challenges, including manufacturability, quality systems, reimbursement context, regulatory considerations, and clinical adoption barriers.
• At least one year of experience supporting DARPA or related federal “ARPA” agencies (IARPA, ARPA-E, HSARPA, ARPA-H).
• Experience supporting a federal or commercial health agency or organization.
• Knowledge of the biomedical research landscape.
• Two or more years of experience in federal healthcare and/or scientific consulting.

Benefits

• Competitive compensation package.
• Anticipated base salary range for this position is $90,000-$220,000 per year.
• This range is a good-faith estimate at the time of posting and reflects the base salary the company reasonably expects to offer for this role.
• Actual base salary will be determined based on lawful, job-related factors, including education, experience, specialized expertise, credentials, geographic location, scope of responsibilities, internal equity, client and contract requirements, and funding availability.
• This position may be eligible for discretionary bonuses, signing or retention incentives, or other variable compensation, as stated in the applicable written offer or plan documents.
• Any bonus or incentive is not guaranteed and is subject to applicable plan terms, individual and company performance, client or contract requirements, funding availability, and applicable law.
• Bonuses and other incentives are separate from base salary and may be modified or discontinued.
• The salary range does not include potential bonuses, other incentive compensation, or benefits.