[Hiring] Scientist II @Simulations Plus

Role Description

The Scientist II will contribute to the technical execution of consulting projects using Quantitative Systems Pharmacology (QSP) and/or Toxicology (QST) models and methodologies. Frequently, consulting projects are conducted in Simulations Plus models, leveraging technical expertise in MATLAB or THALES.

• Design, write, test, and use computer code to build and maintain the sub-model(s), representing core cellular, molecular, and/or biochemical processes in a given model.
• Represent compound pharmacodynamics (PD) and/or mechanism of action (MoA), including translating laboratory data into model parameters and curation of clinical data for calibration/validation.
• Learn and effectively utilize company agentic AI solutions for technical work.
• Contribute to the activities required for successful completion of all goals within consulting projects.
• Contribute (as time allows) to R&D efforts, including updating the “license-ready” versions of the various models and supporting ongoing development of QST models of liver injury (i.e., the DILI-sim consortium).
• Combine technical and project management work, including components such as systems pharmacology modeling, software code development, and maintenance in designated software environments.
• Develop plans to complete all tasks and provide all deliverables within a time frame consistent with the services agreement signed with the sponsor.
• Schedule the necessary meetings including internal and external collaborators.
• Exert leadership in the areas of presentation and report preparation by exhibiting strong skills for effective presentations and reports, applying diligent scientific review, and being timely with execution and responses to feedback.
• Lead consulting projects, upon demonstrating the necessary technical and project management skills and availability of a suitable project.
• Participate in preparation and review of joint manuscripts between the company and the sponsor.
• Manage the effort expended for a given project to remain consistent with the resources allocated for the project per the signed contract.
• Publish work in scientific journals, with minimal review required by their supervisor, including documentation preparation, text development, figure development, and correspondence with editors and peer reviewers.
• Train others on QSP/QST and the various models.
• Other duties as assigned.

Qualifications

• 2+ years of QSP/QST modeling experience or demonstration of the equivalent skill sets.
• Proficiency in mathematics, dynamic systems, drug development.
• General knowledge of relevant therapeutic areas, including clinical endpoints and underlying cell and molecular biology and/or biochemistry.
• Experience with MATLAB, THALES, Julia, SimBiology, Monolix, GastroPlus™, and/or C++ programming.
• Experience with PBPK, PK, popPK and/or PKPD modeling.
• Basic familiarity with large-language models and agentic AI.
• Understanding of how to apply modeling and simulation for maximum impact.
• Strong verbal and written communication skills.
• Maintains a positive attitude while interacting with colleagues and clients.
• Must be able to multitask and have good organizational skills.
• Self-motivated with ability to work with minimal supervision.
• Occasional travel for conferences, meetings, and training.

Education

• Master’s degree in pharmaceutical science, biomedical engineering, or related field.
• PhD in pharmaceutical science, biomedical engineering, or related field preferred.

Benefits

• Fully remote work.
• Flexible schedules.
• Generous vacation policy.
• Affordable health coverage.
• Annual bonus.