[Hiring] Scientist, Computer-aided Drug Design (CADD) & Cheminformatics @X-Chem

Role Description

X-Chem is seeking a candidate for the position of Scientist, Computer-aided Drug Design (CADD) & Cheminformatics to join our team, based in Montreal, QC, or remotely from Ontario. Primary responsibilities include:

• Applying computational chemistry and cheminformatics approaches to support and guide medicinal chemistry projects.
• Developing and maintaining machine learning models.
• Expanding into computational method development and engaging with analytical chemistry and DMPK in the context of machine learning as part of professional development.

This position provides the opportunity to be on the cutting edge of scientific development in cheminformatics and computational chemistry, reporting to the Senior Director, Computational Chemistry. The ideal candidate will bring creativity, curiosity, and a willingness to learn and be flexible.

• Provide computational chemistry and cheminformatics support in collaboration with medicinal chemistry teams to guide project decisions.
• Contribute to the development and application of machine learning approaches for drug discovery (e.g. property prediction) to support compound prioritization.
• Support the development and maintenance of chemistry and experimental data workflows.
• Support data integration and workflow development across the drug discovery pipeline and contribute to data governance.

Qualifications

• Education: BSc and/or MSc Degree in Physical Chemistry, Computer Science or related field, and/or a PhD in the same field.
• Experience: 1 to 3 years of industry experience is desirable.
• Proficiency in at least one programming language (e.g. Python, R, SVL).
• Familiarity with computational chemistry or cheminformatics software (e.g. MOE, Schrodinger, OpenEye, RDKit).
• Basic knowledge of computational chemistry principles.
• Experience with cheminformatics workflows and data processing, DNA-encoded libraries, or CDD Vault is an asset.

Requirements

• Bilingual (French and English).
• Excellent oral and written communication skills.
• Good problem-solving skills.
• Strong organizational skills and attention to detail with the ability to manage multiple priorities effectively.
• Current work authorization in Canada.

Benefits

• Focus on the development and career progression of our people through workshops, training courses, and mentor guidance.
• Competitive compensation (salary and performance incentive) and an interesting benefits package.
• Medical, Dental, STD/LTD and Life Insurance.
• Retirement Plan with employer match.
• Paid vacations starting at 3 weeks plus paid Christmas shutdown.
• Casual dress, vision care including prescription safety glasses.
• Training sessions and workshops, social hours, and team-building company events.