[Hiring] Senior Product Quality Specialist @Genomenon

Role Description

Genomenon is seeking a highly experienced variant interpretation expert for a part-time role. The responsibilities include:

• Perform complex and high-priority variant interpretation, including cases with conflicting clinical and functional evidence.
• Apply ACMG/AMP guidelines to ensure accurate, consistent, and defensible classifications.
• Evaluate clinical and functional literature to support interpretation decisions.
• Ensure interpretations are clinically relevant and aligned with real-world use cases.
• Contribute to high-impact client deliverables across clinical and pharmaceutical contexts.

Additionally, the role involves:

• Applying QA/QC standards across variant interpretation workflows.
• Ensuring consistent use of internal frameworks, HGVS nomenclature, and interpretation criteria.
• Supporting data quality efforts, including review of external data (e.g., ClinVar) and discrepancy identification.
• Contributing to refinement of SOPs, QA processes, and workflows.
• Identifying quality gaps or inconsistencies and proposing improvements.
• Supporting scalable approaches to interpretation as volume and complexity grow.

Qualifications

• 5+ years of hands-on variant interpretation experience in a clinical or equivalent setting.
• Advanced degree (PhD, MS in Genetics/Genomics) or Genetic Counselor (CGC).
• Deep expertise applying ACMG/AMP guidelines in complex scenarios.
• Strong experience evaluating clinical and functional evidence from scientific literature.
• Proficiency in HGVS nomenclature, including normalization and variant disambiguation.
• Demonstrated ability to make independent, high-confidence scientific decisions.
• Ability to work up to 20-hours per week in a remote-first environment (hours will fluctuate based on business volumes).

Requirements

• Experience with ClinVar submissions and resolving interpretation discrepancies (preferred).
• Experience developing or refining SOPs (preferred).
• Exposure to a broad range of disease areas or gene classes (preferred).

Benefits

• Contribute to Scientific Quality at Scale.
• Support high-quality variant interpretation across products, clients, and public data resources.
• Flexible, High-Impact Work.
• Engage in meaningful scientific work in a part-time, contract capacity.
• Make a Real Impact.
• Your work directly supports clinical decisions, patient outcomes, and pharmaceutical research.
• Tackle Meaningful Complexity.
• Work on challenging problems at the intersection of genomics, data, and real-world application.