[Hiring] Senior Director, Program Team Lead @Iovance Biotherapeutics

Role Description

The Senior Director, Program Team Lead owns integrated program strategy for one or more TIL cell therapy assets across early-to-late-stage clinical development. This role connects clinical, CMC, regulatory, and commercial workstreams into a single plan that maximizes clinical probability of success, regulatory approval, and commercial value, all within the context of Iovance's broader portfolio strategy.

The Program Team Lead chairs the cross-functional program team, manages timelines across workstreams, and is the central point of accountability for translating strategy into execution. This individual partners with senior leadership to advance programs from early clinical studies through pivotal trials, global regulatory submissions, and into commercial planning.

The right candidate brings deep oncology development and CMC experience with the judgment to navigate autologous cell therapy. They are as comfortable shaping an early-stage data strategy as they are driving late-stage registration execution, and they ensure every program decision maintains a clear line of sight to clinical success, regulatory approval, and commercial differentiation.

Qualifications

• Advanced degree (PhD, PharmD, MD, MBA, or equivalent).
• 11+ years in clinical drug development with strong CMC experience in oncology, particularly with CGT, especially CAR-T, viral, TIL, and other products.
• Working knowledge of the global clinical and commercial landscape in oncology and cell therapy.
• Strong strategic and analytical skills — able to synthesize inputs from clinical, regulatory, commercial, and CMC functions into clear recommendations.
• Track record leading cross-functional teams through multiple development phases, including regulatory submissions and health authority interactions.
• Proficiency with program and portfolio management tools and timeline oversight.
• Proven ability to influence senior stakeholders and motivate teams without direct authority.
• Comfortable operating in a fast-moving biotech environment with shifting priorities.

Requirements

• Own the program strategy and vision from early development through registration and commercialization, ensuring alignment with Iovance's TIL platform strategy.
• Frame program decisions around clinical probability of success, regulatory path, and commercial value.
• Develop and present strategic options and trade-off analyses to senior leadership and governance bodies.
• Track the competitive landscape in solid tumor oncology and cell therapy; translate insights into program-level actions.
• Work to align SME deliverables with overall development strategy, anticipating risks, proposing alternative scenarios, and working with the cross-functional team to drive accountability.
• Partner with the Program Manager to align domain area strategy & execution plans with asset level strategy across all functions, including Clinical, Regulatory, Commercial, and CMC.
• Own program dashboards/reporting that keeps leadership informed on program status, timelines, strategic roadmap progress, upcoming inflection points, and open risks.
• Serve as the primary strategic voice for assigned programs in governance forums and executive reviews.
• Proactive escalation & driving of resolution recommendations with senior leadership.
• Support due diligence, business development, and investor-related activities for assigned programs.
• Must adhere to Iovance Biotherapeutics’ core values, policies, procedures, and business ethics.
• Perform miscellaneous duties as assigned.

Benefits

• The annual base salary we reasonably expect to pay is listed. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of the role, job duties/requirements, and relevant education, experience, and skills.
• Pay Transparency: $270,000 — $290,000 USD.

Work Environment

• This job operates in a professional or remote office environment and requires operating standard office equipment and keyboards.
• Ability to remain in a stationary position for extended periods.
• Ability to move about within an office or remote workspace and exert up to 10 pounds of force occasionally.
• Visual acuity sufficient for preparing and analyzing data, viewing computer screens, and extensive reading.
• Repetitive motion involving wrists, hands, and/or fingers.
• Ability to communicate effectively to exchange information.
• Ability to engage in analytical, conceptual, and problem-solving activities in a dynamic business environment.