[Hiring] Scientist R&D – Immunohistochemistry (IHC) & Histology @Natera

Role Description

Natera is seeking a highly motivated Scientist, R&D – Immunohistochemistry (IHC) & Histology to join the Oncology Product Development team. This role will focus on the development, optimization, verification, and validation of IHC and tissue-based workflows supporting oncology products and clinical assay development.

The ideal candidate will have strong hands-on experience in IHC assay development and optimization, supported by a solid foundation in histology and FFPE tissue workflows. Experience with automated IHC/ISH staining platforms, particularly the Roche BenchMark ULTRA IHC/ISH System, is highly desirable. Experience with NGS and molecular biology workflows is an additional plus.

Qualifications

• Ph.D. in Pathology, Cancer Biology, Molecular Biology, Cell Biology, Biomedical Sciences, or a related field with a minimum of 2 years of relevant industry experience; or a Master's degree with a minimum of 5 years of relevant industry experience; or a Bachelor's degree with a 6-8+ years of relevant industry experience.

Requirements

• Design and execute development, optimization, verification, and validation studies for IHC, histology, and tissue-based workflows.
• Develop and optimize IHC assays, including antibody selection and titration, antigen retrieval, staining conditions, controls, and assay performance assessment.
• Evaluate and optimize histology and pre-analytical variables, including tissue fixation, FFPE processing, embedding, sectioning, H&E staining, and slide preparation.
• Develop and troubleshoot workflows on automated IHC/ISH staining platforms and investigate staining artifacts, reagent performance, tissue quality, and assay variability.
• Plan and execute moderate- to high-complexity experiments; analyze and interpret results using tools such as Excel, JMP, and image-analysis approaches.
• Collaborate with Pathology, Clinical Laboratory Operations, Quality, Automation, and other cross-functional teams to transfer R&D methods into robust clinical laboratory workflows.
• Author study protocols, development/validation reports, SOPs, and transfer documentation, and provide technical guidance and training during implementation.
• Communicate project progress, experimental findings, risks, and recommendations to project teams and stakeholders.

Benefits

• Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents.
• Natera employees and their immediate families receive free testing in addition to fertility care benefits.
• Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more.
• Generous employee referral program!