[Hiring] Principal Clinical Research Associate @ICON plc

Role Description

At ICON Strategic Solutions, you will work in a sponsor-dedicated model, supported by ICON’s global expertise. As a Principal CRA at ICON, you will oversee and manage clinical trial sites, ensuring studies are conducted in accordance with regulatory requirements, study protocols, and company standards.

Your focus will be on coordinating clinical trial monitoring delivery, resolving issues, supporting CRA team performance, and ensuring successful study execution in a fast-paced environment.

Key Responsibilities

• Perform site qualification, initiation, monitoring, and closeout activities as assigned.
• Verify protocol, GCP, and regulatory compliance while ensuring participant safety and data integrity.
• Identify, communicate, and follow up on study findings, risks, and corrective actions.
• Maintain effective communication with investigators, site staff, and study teams.
• Review monitoring activities and provide guidance, coaching, and support to CRA team members.
• Support study execution through proactive risk management, issue resolution, and operational oversight.

Qualifications

• Proven Lead CRA experience providing oversight, coaching, and mentoring to CRA teams.
• Experience reviewing monitoring reports, ensuring quality standards, and driving follow-up of action items.
• Demonstrated ability to identify, assess, and escalate study risks while applying strong clinical judgment.
• Experience working directly with stakeholders in an FSP and/or biotech environment.
• Strong adaptability and ability to execute within evolving processes and changing priorities.
• Strong knowledge of ICH-GCP, regulatory requirements, and clinical trial operations.
• Relevant life sciences, healthcare, or clinical research qualification, or equivalent industry experience.

Requirements

• This position is intended for experienced Lead CRAs and is not suited for Senior CRAs seeking their first Lead CRA opportunity.

Preferred Qualifications and Experience

• Ophthalmology experience, particularly retina and/or wet AMD studies.
• Experience supporting masked and unmasked clinical trials.
• Prior biotech experience.

Working Conditions

• Willingness to travel as required (approximately 60%).
• Employment with ICON is contingent upon having the legal right to work in the country where the role is based.

Benefits

• Competitive base salary and performance related incentives.
• Health and wellbeing programmes including medical, dental, and vision coverage where applicable.
• Retirement and pension plans.
• Life assurance and disability coverage.
• Employee assistance programmes and wellbeing resources.
• Learning and development opportunities through structured training and career pathways.
• Benefits may vary depending on role and location.

Inclusion and Accessibility

ICON is an equal opportunity employer. We are committed to building an inclusive and accessible workplace where everyone feels valued and supported. If you require reasonable accommodations during the recruitment process, please let us know or submit a request.