[Hiring] Executive Director, Medical Affairs – Digital Innovation & HEOR @Kardigan

Role Description

The Executive Director of Medical Affairs – Digital Innovation & HEOR will lead the strategy, development, and execution of digital and AI-enabled initiatives and HEOR across Medical Affairs for a biopharma company with integrated pharmaceutical and medical device solutions. This role is responsible for transforming how digital enabled data and data evidence partnerships with Prolaio are generated, analyzed, and applied through medical strategy and tactics. Additionally, this role will focus on developing the HEOR and Real World Evidence strategy across the clinical programs at Kardigan and integrated with Prolaio evidence generation capabilities and tactics.

Operating at the intersection of medicine, data science, health economics, and technology, this leader will serve as a key partner to Clinical Development (Kardigan & Prolaio), Data Science, Commercial, and IT functions to ensure digital/AI capabilities and HEOR evidence generation plans are scientifically rigorous, compliant, and aligned with medical and enterprise strategy.

Essential Duties and Responsibilities

• Digital & AI Strategy (Medical Affairs)
  • Define and lead the Medical Affairs digital innovation and AI roadmap with Prolaio, aligned with therapeutic area and enterprise priorities across drug–device portfolios.
  • Identify, prioritize, and operationalize AI/ML and advanced analytics use cases to support medical strategy, insights generation, and scientific exchange.
  • Ensure digital and AI solutions adhere to scientific, ethical, regulatory, and compliance standards across pharmaceutical and medical device contexts.
• Medical Insights, HEOR/RWE & Evidence Enablement
  • Lead technology-enabled approaches to generate medical and economic insights from clinical, observational, and digital data sources.
  • Partner with Prolaio Data Scientists to support outcomes research, value demonstration, and evidence needs using advanced analytics and AI-enabled methodologies.
  • Translate analytical outputs into actionable medical and health economic insights to inform medical strategy, real-world evidence, publications, and external engagement.
• Cross-Functional Collaboration
  • Partner with Clinical Development and Device Development teams to align digital and AI initiatives with clinical programs and post-market evidence needs.
  • Collaborate with Data Science, Digital, and IT teams to design, develop, validate, and deploy AI-enabled solutions.
  • Work with Commercial and Market Access teams (in a medical, non-promotional capacity) to support appropriate use of medical and economic insights.
  • Engage Legal, Compliance, Privacy, and Quality partners to ensure responsible use of AI and data in pharmaceutical and medical device environments.
• Team Leadership & Capability Building
  • Establish operating models, governance frameworks, and best practices for digital and AI initiatives, as well as HEOR/RWE evidence generation.
  • Advance digital, AI, and HEOR literacy across the Medical Affairs organization.
• External Engagement & Innovation Ecosystem
  • Evaluate and manage external partnerships with technology vendors, analytics providers, medical device companies, digital health organizations, and academic medical centers and/or health systems.
  • Engage external experts, academic partners, and key opinion leaders on digital innovation and outcomes-focused initiatives.
  • Represent Medical Affairs in internal and external forums related to digital health, AI, and value-based healthcare.

Qualifications

• Advanced degree required (MD, PharmD, PhD, or equivalent scientific degree).
• 10–12+ years of experience in Medical Affairs, HEOR, or a related function within biopharma and/or medical device organizations.
• Demonstrated experience leading or partnering on digital innovation, advanced analytics, or AI-enabled initiatives.
• Working knowledge of HEOR methodologies, real world outcomes research, and value evidence generation.
• Understanding of regulatory and compliance considerations for both pharmaceuticals and medical devices.
• Proven ability to lead cross-functional, matrixed teams.

Preferred Skills

• Experience spanning both pharmaceutical and medical device portfolios.
• Familiarity with AI governance, validation, and responsible AI principles in healthcare.
• Experience working with external technology, device, or digital health partners.
• Publication and scientific presentation experience including outcomes or value-based evidence.
• Experience managing teams in a matrixed environment, with proven ability to influence and lead through change.

Compensation

Exact Compensation may vary based on skills, experience and location. Pay range: $275,000 — $358,000 USD.