[Hiring] Principal, Volume Forecasting @GeneDx

Role Description

We are seeking a Principal, Volume Forecasting to own and advance GeneDx's end-to-end forecasting capability. This is a senior individual contributor role with high autonomy and broad cross-functional influence. You will build rigorous, data-driven models, drive full adoption of AI and automation tooling, lead forecasting cycles, and deliver the insights that shape strategic decisions across our diagnostics business — all with minimal leadership support in a fast-paced, high-growth organization.

Job Responsibilities

• Own the design, build, and continuous improvement of driver-based volume forecast models integrating historical trends, pipeline data, seasonality, payer/channel mix, and market intelligence across all product lines.
• Select and apply appropriate statistical and machine learning forecasting methodologies (e.g., ARIMA, exponential smoothing, regression, ensemble/ML methods) based on data characteristics, forecast horizon, and business context.
• Drive full adoption of AI and automation across the forecasting scope, from data ingestion and feature engineering through model training, validation, and reporting.
• Lead monthly, quarterly, and annual forecasting cycles end-to-end, coordinating inputs from Sales, Marketing, Operations, and Finance to ensure alignment and accuracy.
• Deliver objective forecasting scorecards tracking volume targets, forecast accuracy and variance; lead root-cause analysis in updates to Commercial, Operations, and Finance.
• Produce and maintain a rolling volume forecast for incoming test volumes, delivered to the Supply Chain team on a defined cadence.
• Conduct scenario planning and sensitivity analyses to assess the impact of market changes, new product launches, pricing actions, and strategic initiatives on demand forecasts.
• Partner with Commercial, Revenue, and Strategic Finance leaders to provide volume inputs for revenue forecasts, long-range plans, and board-level materials.
• Design and maintain high-visibility forecasting dashboards and automated reporting.
• Serve as the organizational authority on volume forecasting methodology, data quality, and accuracy standards.

Qualifications

• Bachelor's degree in Statistics, Mathematics, Engineering, Economics, Finance, or a quantitative field; Master's degree preferred.
• 8–12+ years of experience in Forecasting, Demand Planning, Analytics, or quantitative Consulting within diagnostics, healthcare, biotech, life sciences, or a comparably data-intensive industry.
• Deep expertise in statistical forecasting techniques (e.g., ARIMA/SARIMA, exponential smoothing, time-series decomposition, regression) and practical experience applying machine learning methods (e.g., gradient boosting, random forests) to demand forecasting.
• Proficiency in Python or R for model development and automation; ability to build production-quality, repeatable forecasting pipelines.
• Proficiency in SQL and experience with cloud data platforms (e.g., Snowflake, BigQuery, Redshift); hands-on experience with Tableau or Power BI for dashboard design and automated reporting.
• Experience with modern AI/ML forecasting tools and platforms (e.g., Prophet, statsmodels, scikit-learn, DataRobot, or equivalent).
• Proven track record building driver-based and segment-level forecasts that inform capacity planning, resource allocation, and revenue decisions.
• Demonstrated structured problem-solving ability: framing ambiguous business challenges, designing analyses, and distilling results into actionable insights for executive audiences.
• Proven ability to operate independently with minimal direction — setting priorities, managing timelines, and driving outcomes across multiple concurrent workstreams.
• Effective cross-functional partner and communicator who can translate forecasting insights into operational actions and influence senior stakeholders without positional authority.

Work Environment

This is a fully remote position. The employee will work from a home office or other suitable remote location with reliable high-speed internet access. Work is performed in a climate-controlled environment using standard office equipment including computer, phone, and video conferencing tools.

Physical Demands

• Sitting for extended periods (up to 8 hours per day).
• Repetitive use of hands and fingers for typing and mouse operation.
• Visual acuity for reading computer screens and documents.
• Ability to communicate effectively via phone and video calls.
• Occasional lifting of up to 10 pounds (office supplies, equipment).

Pay Transparency, Budgeted Range

$150,000 — $170,000 USD

Benefits

• Paid Time Off (PTO)
• Health, Dental, Vision and Life insurance
• 401k Retirement Savings Plan
• Employee Discounts
• Voluntary benefits

Company Description

At GeneDx, we create, follow, and are informed by cutting-edge science. With over 20 years of expertise in diagnosing rare disorders and diseases, and pioneering work in the identification of new disease-causing genes, our commitment to genetic disease detection, discovery, and diagnosis is based on sound science and is focused on enhancing patient care.