[Hiring] Senior Principal Software and AI Engineer @BeiGene

Role Description

We are seeking a Sr. Principal Software and AI Engineer to serve as the senior technical authority for AI-powered applications across drug development, with a primary focus on protocol generation and clinical trial execution. In this hands-on senior technical leadership role, you will help shape the R&D AI strategy and set technical direction for the engineering team, while building critical components yourself and setting best practices for AI-native development within a disciplined, validated SDLC.

• Build AI and Agentic Applications: Architect, build, and deploy AI and agentic powered applications that accelerate protocol generation and clinical trial execution, from study design through operational delivery.
• Collaborate Broadly: Partner with clinicians, medical writers, statisticians, data scientists, clinical operations, and product teams to embed AI into regulated clinical development workflows.
• Shape Architecture: Define scalable, reliable platform architecture for multi-agent orchestration, model and tool integration, and the full LLMOps lifecycle.
• Set Standards: Establish best practices for AI-native development, evaluation, testing, observability, and continuous performance monitoring within a validated SDLC.
• Drive Innovation: Assess frontier and open-weight models, agent frameworks, and tooling, and make sound build, buy, and model sourcing decisions.
• Ensure Compliance: Uphold GxP, data privacy, security, and responsible AI standards, with traceability, auditability, and human oversight built into every system.

Qualifications

• Bachelors with 7+ years, Masters with 5+ years or PhD with 3+ years.
• Software and AI/ML engineering experience, including experience as a tech lead or principal engineer owning large-scale AI products end to end.
• Experience in the pharmaceutical or life sciences industry is strongly preferred.
• Proven success shipping production-grade AI and agentic applications that deliver measurable scientific or business impact, ideally in a regulated environment.

Requirements

• Deep backend expertise in Python (preferred) and/or .NET.
• Hands-on experience with relational, search, and graph data stores such as PostgreSQL, Elasticsearch, and Neo4j.
• Proven ability to design and manage enterprise knowledge architecture, including ontology design, knowledge graphs, and retrieval.
• Experience with clinical protocol development, study design, or clinical trial operations.
• Working knowledge of GxP, computer system validation, and emerging regulatory guidance on AI in drug development.
• Proven ability to act as tech lead, owning product direction and delivery while mentoring senior engineers.

Benefits

• Salary Range: $137,400.00 - $182,400.00 annually.
• Participation in the annual bonus plan for Non-Commercial roles and an incentive compensation plan for Commercial roles.
• Opportunity to own shares of BeOne Medicines Ltd. stock through discretionary equity awards and Employee Stock Purchase Plan.
• Comprehensive benefits package including Medical, Dental, Vision, 401(k), FSA/HSA, Life Insurance, Paid Time Off, and Wellness.

Company Description

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.