[Hiring] Structural Evolutionary Biologist @Invivyd

Role Description

We are seeking a Structural Evolutionary Biologist to join Invivyd’s Research and Development Team. The ideal candidate brings a strong foundation in molecular evolution, protein structure and computational analysis, with the ability to translate large-scale sequence data into mechanistic insights that inform therapeutic monoclonal antibody development.

• Lead an effort that coordinates inputs from microbiologists, evolutionary biologists and antibody engineers to guide programming efforts to develop bioinformatic tools for use in antibody discovery and development
• Analyze large sequence datasets to identify evolutionary trends, structural constraints, variant hotspots, and functional motifs in multiple viral target proteins
• Develop, maintain, and optimize computational pipelines for sequence processing, structural prediction, phylogenetic analysis, and evolutionary modeling
• Curate wastewater and clinical sequence database connectivity pipelines
• Support protein engineering and antibody programs by providing structural and evolutionary risk assessments and actionable insights
• Generate figures and animations that effectively communicate observed trends in virus evolution and target structural dynamics
• Author non-clinical study reports related to pathogen surveillance in support of regulatory filings
• Serve as primary point of contact for collaborations and contracts with external partners
• Manage a team of programmers and developers
• Collaborate closely with cross-functional teams, including other research and development groups, preclinical, clinical and regulatory teams

Qualifications

• PhD in a relevant scientific discipline (e.g., Computational Biology, Evolutionary Biology, Molecular Biology, Structural Biology, Biochemistry, Immunology, Microbiology)
• Demonstrated expertise in microbial molecular evolution, sequence analysis, and phylogenetics
• Experience working with large biological data sets and establishing quality assessment workflows for regularly updated databases
• Programming skills in Python and JavaScript
• Proficiency in design and maintenance of customized computational biology tools and cloud-based bioinformatics suites
• Experience in managing CROs and external collaborations, including budgeting and timeline management
• Strong problem-solving skills and the ability to adapt to evolving project needs
• Excellent verbal and written communication skills
• Ability to work independently as well as part of a multidisciplinary team
• Highly organized with strong attention to detail
• Inclusion of a coding portfolio as part of the application (a link to GitHub repository is preferred)
• At least 2 years of experience in the pharmaceutical or biotechnology industry, with a focus on antibody drug discovery and development or infectious diseases - preferred
• Experience with SARS-CoV-2 research or similar virology-related projects - preferred
• Experience in regulatory interactions and patenting strategies - preferred

Company Description

At Invivyd, Inc., we take those numbers very seriously and we come to work each day on a mission to deliver protection from serious viral infectious diseases, beginning with SARS-CoV-2. Invivyd deploys a proprietary integrated technology platform unique in the industry designed to assess, monitor, develop, and adapt to create best in class antibodies.

• In March 2024, Invivyd received emergency use authorization (EUA) from the U.S. FDA for a monoclonal antibody (mAb) in its pipeline of innovative antibody candidates.
• In October 2025, the FDA cleared the company's Investigational New Drug (IND) application and provided feedback to advance the company's REVOLUTION clinical program, Invivyd's development program for VYD2311, a vaccine alternative monoclonal antibody being investigated for the prevention of COVID-19.