[Hiring] Lead Bioinformatics Scientist @Natera

Role Description

Natera is seeking a Lead Bioinformatics Scientist to join our Oncology Bioinformatics team and support the development, validation, and clinical application of our NGS-based assays. The ideal candidate has a strong background in data analysis for wet lab support and extensive experience with NGS data, with a focus on building solutions for oncology applications.

• Shape the analytical validation strategy for an NGS assay.
• Design and analyze feasibility and performance evaluation studies.
• Generate real-world evidence demonstrating clinical utility.
• Work with interdisciplinary teams to turn complex, multi-source data into actionable recommendations.
• Support research, product development, validation, regulatory submissions, clinical studies, and scientific publications.

Qualifications

• Master’s degree in bioinformatics (or a related field) with 10 years of post-graduate experience, or PhD with 5 years of post-graduate experience (preferred).
• Expert knowledge of bioinformatics tools for NGS, including sequencing QC and secondary analysis such as variant calling.
• Experience with WES/WGS/targeted sequencing of tissue and cfDNA, and with somatic variant calling (SNVs, indels, CNVs, fusions).
• Working knowledge of statistical methods for assay performance evaluation.
• Strong programming and scripting skills in Python, R, and shell.
• Fluency in exploratory data analysis and visualization of complex datasets.
• Deep understanding of NGS workflows from sample extraction to sequencing.
• Ability to communicate effectively with wet lab groups and cross-functional partners.
• Ability to work independently while managing multiple objectives and timelines.
• Comfort adapting quickly when experimental results change the plan.

Requirements

• Experience supporting regulated or clinical-grade assay development (e.g., CLIA/CAP, FDA submissions).
• Familiarity with clinical genomics, including oncogenic drivers, actionable biomarkers, targeted therapies, and variant interpretation in oncology.
• Experience with translational or real-world data analysis, including integrating clinical and genomic data.

Benefits

• Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents.
• Free testing for Natera employees and their immediate families.
• Fertility care benefits.
• Pregnancy and baby bonding leave.
• 401k benefits.
• Commuter benefits.
• Generous employee referral program.

Company Description

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

• The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers, and many other professionals from world-class institutions.
• We care deeply for our work and each other.
• When you join Natera, you’ll work hard and grow quickly.
• You’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.