[Hiring] Senior Bioinformatics Scientist @Natera

Role Description

Natera is seeking a Senior Bioinformatics Scientist to join our Bioinformatics team dedicated to early cancer detection. As a core member of the Research and Development department, you will play a pivotal role in designing and implementing innovative computational solutions. The ideal candidate possesses a robust background in algorithm development, high-throughput biological data analysis, and scalable pipeline architecture.

In this role, you will:

• Innovate, design, develop, and validate advanced algorithms and statistical models to extract actionable insights from large-scale genomic datasets for early cancer detection.
• Co-architect, implement, and deploy automated analysis workflows for clinical diagnostics, ensuring robust performance for variant calling, fusion detection, and automated quality control.
• Contribute to rigorous code reviews, maintain comprehensive technical documentation, and drive the continuous optimization of core computational infrastructure.
• Analyze complex multi-omic data using high-performance internal pipelines, collaborating closely with wet-lab scientists and statisticians to meet critical research milestones.

Qualifications

• Ph.D. in Bioinformatics, Computer Science, Statistics, Cancer Biology, or a related quantitative field.
• 0–3 years of professional or postgraduate experience in bioinformatics or computational biology.

Requirements

• Excellent communication skills with a demonstrated ability to present complex computational findings to diverse cross-functional stakeholders.
• Deep expertise in high-throughput DNA sequencing (NGS) analysis, including sequence alignment, mapping, and clinical-grade variant calling.
• A proven track record of developing state-of-the-art, high-impact bioinformatics methodologies.
• Advanced knowledge of data structures, algorithm design, and computational complexity analysis.
• High proficiency in Python and its scientific ecosystem (NumPy, Pandas, Scikit-learn) for data manipulation and automation.
• Experience with workflow orchestration languages (WDL preferred) for building and versioning scalable bioinformatics pipelines.
• Experience with cloud-based distributed computing environments, specifically AWS.
• Familiarity with contemporary analytical techniques and biomarkers in cancer biology.
• Working knowledge of public genomic databases such as TCGA, COSMIC, or OncoKB.
• Proficiency in Linux environments, including command-line tools and shell scripting.

Benefits

• Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents.
• Natera employees and their immediate families receive free testing in addition to fertility care benefits.
• Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits, and much more.
• Generous employee referral program.

Company Description

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers, and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.