[Hiring] Staff Bioinformatics Engineer, Clinical Applications @Helix

Role Description

As a Senior/Staff Bioinformatics Engineer, Clinical Applications, you will:

• Productionize curation workflows that support both classical and modern AI/ML approaches to variant classification.
• Automate evidence integration from sources such as ClinVar, gnomAD, and PubMed.
• Collaborate closely with scientists, product, and clinical stakeholders to ensure software solutions meet scientific and product requirements.
• Direct AI coding agents to accelerate development of curation pipelines, applying engineering judgment to validate correctness, security, and architectural fit before deployment.
• At Senior level, own defined projects end to end, make technical decisions within agreed priorities and architecture, and raise trade-offs that affect broader systems.
• At Staff level, independently frame ambiguous problems, set technical direction, and make consequential architecture and prioritisation decisions across the product area.

Qualifications

• Bachelor's degree in Science or related field with 7+ years (Senior) or 9+ years (Staff) of professional software development experience.
• Or, a Master's or Ph.D. with 3+ years (Senior) or 5+ years (Staff) of professional software development experience.
• Advanced proficiency in production-quality Python, relational databases, and cloud platforms such as AWS.
• Experience productionizing and scaling AI/ML software, especially agentic systems built with frameworks such as LangChain or LangGraph.
• Experience collaborating with scientists to integrate bioinformatics/NGS tools and databases into production workflows.
• Strong judgment evaluating AI-generated code and pipeline logic for correctness, security, and maintainability before it reaches production.

Requirements

• Experience in clinical genomics, such as ACMG guidelines, clinical diagnostics, or Human Phenotype Ontology (HPO) terms.
• Experience developing regulated software, such as software as a medical device.
• At Staff level, the role may have the opportunity to take on people leadership responsibilities.
• Experience mentoring or managing others, or an interest in developing as a people leader, is a plus.

Benefits

• Comprehensive Health Insurance with Date of Hire eligibility.
• Above average employer paid premium coverage.
• 12 weeks Helix Paid Parental Leave option.
• 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire.
• Comprehensive Well-Being Benefits.
• Flexible PTO.
• Remote options for many roles and a home office stipend.

Expected Interview Process

• Recruiter Screen
• Manager Screen/Tech Screen
• Onsite
• Offer

Expected Pay For This Role

• Expected Helix Base: $161,500 - $219,625
• Expected Helix Discretionary Annual Bonus: 15% of your annual salary
• Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model.

What To Expect During Your First 90 days

• First 30 days: you’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders.
• Day 30 - 60: you’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities.
• Day 60 - 90: you’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission.