[Hiring] Portfolio Operations Manager @Genentech

Role Description

The Portfolio Operations Manager is responsible for the operating system that allows CE to evaluate, prioritize, sequence, and govern enterprise work as one portfolio. This role owns intake of proposed enterprise work, the prioritized CE portfolio roadmap, governance and decision cadence, and the integrated view of dependencies, duplication, capacity, and tradeoffs. The manager partners with CE Leadership, Enterprise Operations, Regions, HEDs, RBO teams, and other stakeholders to ensure the organization focuses resources on the work that matters most and can make transparent portfolio decisions when priorities compete.

Qualifications

• Bachelor's degree required
• 8-10 years of pharmaceutical, biotechnology, consulting, commercial, portfolio, strategy, program management, and/or operations experience including leading, coaching or mentoring others strongly preferred
• Demonstrated experience with portfolio management, prioritization, governance, or resource planning
• Experience facilitating senior leadership decisions involving competing priorities and tradeoffs
• Strong analytical, synthesis, and project/program management capabilities
• Demonstrated ability to influence across a complex matrixed organization
• Strong communication and executive presentation skills
• Ability and willingness to travel as required for internal and external business meetings

Requirements

• Maintain the integrated CE enterprise portfolio across initiatives, launches, RBO work, and field-partner commitments.
• Translate CE strategy and leadership priorities into a prioritized portfolio roadmap.
• Create visibility to timing, sequencing, interdependencies, and major portfolio milestones.
• Identify duplication, overlap, and opportunities to combine or simplify work across the portfolio.
• Ensure portfolio views are current, decision-oriented, and useful to CE Leadership and operating teams.
• Own the intake and evaluation process for proposed enterprise work.
• Establish clear criteria for strategic alignment, impact, urgency, effort, capacity, and enterprise value.
• Facilitate prioritization discussions and develop recommendations when demand exceeds available capacity.
• Ensure new work has a clear sponsor, problem statement, intended outcome, and required decision before entering the portfolio.
• Route approved work to the appropriate Enterprise Operations manager, lead, or enabling team for execution.
• Manage the portfolio governance cadence and prepare decision materials for CE Leadership and CELT as needed.
• Create transparent decision logs, escalation paths, and follow-through on portfolio choices.
• Provide concise synthesis of what is changing, why it matters, and what decisions or tradeoffs are required.
• Ensure governance focuses on material decisions, risks, and dependencies rather than routine status reporting.
• Partner with initiative and launch teams to maintain accurate portfolio status and milestone visibility.
• Maintain an integrated view of enterprise capacity, demand, major dependencies, and resource constraints.
• Develop capacity, sequencing, and tradeoff recommendations across competing priorities.
• Integrate RBO work into the broader CE portfolio view so Regional and HED-supported commitments are visible and prioritized.
• Surface cross-portfolio risks and constraints early enough to enable leadership action.
• Partner with Enterprise Initiatives and Launch Operations to resolve conflicts and coordinate shared resources.
• Lead, coach, and develop Enterprise Operations Leads assigned to portfolio and RBO work.
• Set standards for portfolio data quality, governance materials, decision support, and milestone tracking.
• Allocate team capacity to the highest-priority portfolio needs and time-sensitive decisions.
• Build strong portfolio management capabilities, tools, and ways of working across the team.
• Contribute to common Enterprise Operations standards, talent practices, and continuous improvement.

Benefits

• A discretionary annual bonus may be available based on individual and Company performance.
• This position also qualifies for the benefits detailed at the link provided below.