[Hiring] Principal Product Manager @Natera

Role Description

Natera is at the forefront of personalized genetic testing, transforming the management of disease worldwide. We are seeking an experienced Principal Digital Product Manager to join our Oncology Comprehensive Genomic Profiling (CGP) Product Engineering team. In this senior individual contributor role, you will serve as the product lead for our most complex platform initiatives — owning end-to-end product strategy and execution across a sophisticated system of interconnected software products.

You will act as the product backbone for our most critical "Pillar" projects. Success in this role demands mastery from three dimensions:

• Partnership with commercial teams to define product strategy/roadmap based on market needs.
• Deep fluency in how end users - lab operations, clinical teams, customer success teams - actually work.
• Close collaboration with Engineering, R&D, and PMO on product design and delivery.

Crucially, while this is an individual contributor role, you will operate as a central leader — driving consensus, roadmap alignment, and product excellence through influence rather than formal authority across Engineering, R&D, Commercial, and Clinical teams.

Key Responsibilities

• Strategic Leadership & Vision
  • Define Long-Term Vision: Develop and execute multi-year software product roadmaps for critical business units, balancing rapid prototyping with long-term commercial stability.
  • Architect Complex Solutions: Act as a high-level Architect, translating broad business goals into detailed functional workflows.
  • Founder's Mindset: Champion a culture of high agency and urgency, making quick, data-driven decisions in ambiguous situations.
  • Cross-Functional Influence: Lead by expertise rather than authority, aligning stakeholders across R&D, Engineering, Operations, Quality, and Regulatory.
• Product Excellence & Execution
  • End-to-End Ownership: Lead the full product lifecycle for complex software solutions.
  • Technical Translation: Serve as the primary domain expert, translating complex scientific, clinical, or technical requirements.
  • Operational Immersion: Advocate for internal and external users by shadowing operations and engaging with customers.
  • Systems Thinking: Maintain a "big picture" view of how software systems interact across the entire data lifecycle.
  • Agile Mastery: Lead with the rigor of a seasoned project manager, owning product backlogs and driving Agile ceremonies.
  • AI-Native Product Development: Pioneer the use of LLMs and generative AI tools to accelerate product discovery.
• Regulatory & Quality Leadership
  • Compliance Champion: Partner with Quality and Regulatory teams to ensure all products comply with relevant global standards.
  • Risk Mitigation: Proactively identify and mitigate product risks.
• Mentorship & Craft
  • Leveling Up the Org: Mentor and guide Senior Product Managers and cross-functional team members.
  • Culture Building: Foster a product culture of accountability, technical rigor, and cross-functional collaboration.

Qualifications

• 10+ years of product management experience in high-scale software or biotech environments.
• Demonstrated experience building and launching new software products from the ground up.
• Deep experience in highly regulated environments (e.g., FDA design controls, HIPAA).
• Strong ability to understand complex technical architectures and communicate effectively.
• Hands-on experience using LLMs and generative AI tools.
• Exceptional written and verbal communication skills.
• BS/MS in a relevant technical, scientific, or quantitative discipline; MBA or equivalent experience is a plus.

Knowledge, Skills, and Abilities

• High Agency & Technical Initiative: Natural builder who thrives in fluid, fast-moving environments.
• Deep Systems-Level Cognition: Expert-level mastery of the system from architectural depth and functional fluency.
• Cross-Functional Leadership through Influence: Operate as a central leader without formal authority.
• User-Centric Validation Ethos: Validate that software delivers on its promise for real users.

Benefits

• Comprehensive medical, dental, vision, life, and disability plans for eligible employees and their dependents.
• Free testing for employees and their immediate families.
• Fertility care benefits.
• Pregnancy and baby bonding leave.
• 401k benefits.
• Commuter benefits.
• Generous employee referral program.