[Hiring] Senior Director, Clinical Pharmacology & Pharmacometrics @Parabilis Medicines

Role Description

The Senior Director of Clinical Pharmacology & Pharmacometrics (CPP) provides scientific, functional, and operational leadership across assigned drug development programs. Reporting to the VP, Head of Clinical Pharmacology, this individual is responsible for designing and executing program-level clinical pharmacology and pharmacometric strategies, ensuring their integration into global development plans. The Senior Director works cross-functionally with Clinical Development, DMPK, Regulatory, and Biostatistics to optimize dose selection, study design, and quantitative decision-making from early to late development.

Key Responsibilities

• Lead the design and implementation of clinical pharmacology and pharmacometrics strategies for assigned programs, from early development through registration and lifecycle management.
• Integrate PK/PD modeling, exposure–response, and quantitative pharmacology to support data-driven decision-making and model-informed drug development (MIDD).
• Collaborate with the VP, Head of Clinical Pharmacology, to ensure alignment with the overall departmental and organizational strategy.
• Serve as the global CPP lead on cross-functional project teams, providing scientific guidance on study design, dose rationale, and risk–benefit assessment.
• Partner with Translational Medicine, Biomarker Sciences, and Biostatistics to incorporate quantitative and mechanistic insights into clinical development plans.

Operational Excellence

• Oversee planning, conduct, and interpretation of clinical pharmacology studies (e.g., FIH, DDI, food effect, special population studies).
• Ensure timely and high-quality preparation of study protocols, analysis plans, and reports.
• Author and review clinical pharmacology sections of regulatory submissions (IND, CTA, NDA, BLA) and represent the function in interactions with global health authorities (FDA, EMA, PMDA, NMPA).
• Support cross-functional integration of modeling and simulation into global regulatory strategies and provide scientific input to agency queries.

Modeling, Simulation & Innovation

• Apply and oversee population PK/PD, PBPK, exposure–response, and disease modeling approaches to support dose selection, trial design, and risk management.
• Promote the use of innovative modeling techniques, including AI/ML, Bayesian methods, and quantitative systems pharmacology.
• Drive implementation of new tools and processes that enhance the impact and efficiency of model-informed development.

Leadership & Mentorship

• Provide scientific and functional leadership to clinical pharmacology and pharmacometrics team members working on assigned programs.
• Mentor and develop staff to foster scientific excellence, collaboration, and continuous learning.
• Contribute to departmental initiatives, best practice development, and knowledge sharing in partnership with the VP and other senior leaders.
• Represent Clinical Pharmacology in cross-functional governance discussions and external scientific forums.

Qualifications

• PhD, PharmD, MD, or equivalent in Clinical Pharmacology, Pharmaceutical Sciences, or a related quantitative discipline.
• 12+ years of experience in clinical pharmacology, pharmacometrics, or quantitative drug development in the biopharmaceutical industry.
• Demonstrated success in designing and leading clinical pharmacology strategies at the program or portfolio level.
• Strong understanding of regulatory expectations (FDA, EMA, PMDA, NMPA) for clinical pharmacology and modeling & simulation.
• Proficiency in modeling and data analysis tools (e.g., NONMEM, Monolix, Phoenix NLME, MATLAB, R).
• Proven ability to lead in matrixed environments, influence cross-functional teams, and drive decision-making.
• Experience with both small molecules and biologics; exposure to novel modalities (e.g., gene or cell therapies) preferred.
• Excellent communication, collaboration, and presentation skills.
• Demonstrated use of AI tools in your current role and responsibilities is required. Advanced or innovated use of AI is a strong plus.

Benefits

• The base salary target for this position is $265,000-$320,000 per year, depending on experience, qualifications, and internal practices.
• Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.

Core Values

• Growth-Minded: We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent: We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused: We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In: We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.