[Hiring] Principal Scientist, Formulation Development @Praxis Precision Medicines

Role Description

We’re looking for a Principal Scientist, Formulation Development to lead drug product development from early discovery through late-stage clinical development. You’ll translate promising compounds into robust, phase-appropriate formulations and scalable manufacturing processes, partnering closely with Discovery, CMC, Regulatory, and external development partners. This role combines deep formulation expertise with hands-on scientific leadership.

• Lead formulation strategy across programs, representing Formulation/Pharmaceutical Development on CMC and multidisciplinary project teams.
• Design, oversee, and interpret formulation studies to characterize novel drug candidates, including small molecules and/or ASOs.
• Develop phase-appropriate formulations and manufacturing processes using sound formulation, material characterization, and pharmaceutical manufacturing principles.
• Partner with Discovery and other functions to provide timely, high-quality formulation support for preclinical studies.
• Drive technical execution with CDMOs, providing scientific oversight for formulation and process development.
• Author and contribute to technical and regulatory documents, including formulation development reports and CMC sections of INDs, IMPDs, NDAs, and related submissions.
• Influence and enable others by guiding scientists and external partners, bringing together cross-functional teams.

Qualifications

• PhD in pharmaceutical sciences, chemical or biochemical engineering, chemistry, or a related scientific discipline, with 8+ years of relevant industry experience.
• Deep understanding of physicochemical and biopharmaceutical properties and how they inform formulation and drug product design.
• Demonstrated experience leading formulation development and manufacturing process development from early-stage work through clinical supply.
• Strong scientific judgment and a track record of creative problem-solving in complex development environments.
• Excellent communication and interpersonal skills, with the ability to influence across functions.
• Highly organized, detail-oriented, and able to manage multiple priorities while maintaining a high bar for quality.
• Self-directed and comfortable making decisions, challenging assumptions, and taking ownership without waiting for direction.
• Brings curiosity, innovation, urgency, integrity, and confidence to the work and thrives in a fast-moving, entrepreneurial environment.

Requirements

• The physical and mental requirements of our roles include regular use of a computer, devices or other office equipment, clear communication, and occasional movement.
• Comfort with screen work, basic hand coordination, and focus.
• Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.

Benefits

• 99% of the premium paid for medical, dental and vision plans.
• Company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage.
• Dollar-for-dollar match up to 6% on eligible 401(k) contributions.
• Long-term stock incentives and ESPP.
• Discretionary quarterly bonus.
• Extremely flexible wellness benefit.
• Generous PTO, paid holidays, and company-wide shutdowns.
• Joining a phenomenal crew of colleagues who are smart, engaged, and inspiring.

Company Description

Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. Our core values of Trust, Ownership, Curiosity, and Results are foundational to every aspect of our business.

• Guided by our core values, we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion.
• We are an equal opportunity employer and committed to providing opportunities to all qualified applicants.