[Hiring] Lead Bioinformatician @Natera

Role Description

Natera is seeking a Lead Bioinformatician to advance the algorithmic foundations of our diagnostic assays supporting Women’s and Organ health. This is an individual contributor role. You will bring the genomics expertise the team needs to pull reliable signals out of sequencing data that is often ambiguous.

You will build the methodological foundations and implement the algorithms needed for detecting variants (SNVs, Indels, CNVs, SVs) that are hard to call accurately in low fraction (fetal, donor cfDNA) samples. The ideal candidate will have deep experience in algorithmic genomics, strong programming skills, and a passion for developing scalable, clinically impactful computational tools.

Primary Responsibilities:

• Panel and Assay Science:
  • Provide genomics algorithm insights to our expanded panel roadmap, including which genes are worth considering and why.
  • Work with Product, the Laboratory Directors, and Research to define the approach for analytically difficult genes and assay edge cases.
  • Weigh what is scientifically defensible against what is technically possible.
• Caller Strategy and Method Development:
  • Define the computational strategy for new targeted and special-purpose callers.
  • Help decide when a new caller is justified and when an existing method should be extended.
  • Prototype and benchmark new methods, and work with the engineering team to get methods into production.
• Scientific Investigation and Escalation:
  • Serve as a genomics consultant on complex production escalations.
  • Separate biological causes from analytical and pipeline ones.
  • Turn one-off investigations into durable rules and design changes that reduce repeat work.
• Data Quality and Cross-functional Partnership:
  • Act as bioinformatics liaison with Variant Management, Reporting, and Laboratory Operations on data quality, variant representation, and system integration.
  • Provide the scientific rationale that the accountable Quality and Laboratory functions rely on when they decide a method is ready to deploy.
• Ways of Working:
  • Help define what correct looks like for AI-assisted scientific investigation.
  • Provide tooling and ramp time for candidates from restricted environments.

What success looks like after a year:

• Contributed to the scientific and bioinformatics rationale of product roadmaps.
• Deployment-readiness criteria for new analysis methods exist and are in use.
• You have contributed to at least one new or extended caller yourself.
• You take on the bioinformatics aspects inside complex production investigations without waiting to be assigned them.
• Other groups know they can bring genomics questions about our assays to you.

Qualifications

• Degree in Bioinformatics, Computational Biology, Bioinformatics, Human Genetics, or a related field.
• 4+ years analyzing short-read sequencing data for screening or diagnostic applications.
• Experience contributing to the bioinformatics workflows behind a sequencing assay or panel.
• Experience seeing a complex investigation through to resolution across biological, analytical, and systems-level causes.

Requirements

• Experience developing, validating, or benchmarking bioinformatics methods (e.g. SNVs, CNVs, SVs), particularly for analytically difficult regions.
• Proficient in Python with demonstrated experience prototyping bioinformatics tools or callers.
• Enough human genetics depth to contribute to the panel design: variant spectrum, population frequency, and where compromises on accuracy can (and cannot) be made.
• Familiarity with identifying regions where short reads cannot be placed with confidence.
• Experience contributing to study designs or performance criteria for a bioinformatics analysis method.

Benefits

• Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents.
• Free testing for Natera employees and their immediate families.
• Fertility care benefits.
• Pregnancy and baby bonding leave.
• 401k benefits.
• Commuter benefits.
• Generous employee referral program.